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Related Experiment Videos

Bone marrow transplantation and cataract development

J P Dunn1, D A Jabs, J Wingard

  • 1Department of Ophthalmology, Johns Hopkins University, Baltimore, Md.

Archives of Ophthalmology (Chicago, Ill. : 1960)
|October 1, 1993
PubMed
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Posterior subcapsular cataract is uncommon after bone marrow transplantation (BMT). Corticosteroid dose and duration are key risk factors, not total body irradiation, and surgery outcomes are favorable.

Area of Science:

  • Ophthalmology
  • Hematology
  • Transplantation Medicine

Background:

  • Bone marrow transplantation (BMT) can lead to various complications.
  • Posterior subcapsular cataract (PSC) is a known ocular complication post-BMT.

Purpose of the Study:

  • To identify risk factors for PSC development after BMT.
  • To evaluate outcomes of cataract extraction in BMT patients.

Main Methods:

  • Retrospective case-control study involving 366 patients who survived at least 1 month post-BMT.
  • Compared risk factors between patients who developed PSC and those who did not.
  • Analyzed data on BMT type, pretransplantation regimen, malignancy, complications, and medications.

Main Results:

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  • PSC developed in 10.9% of patients.
  • Univariate analysis linked PSC to total body irradiation, chronic graft-vs-host disease, allogeneic bone marrow, and corticosteroid therapy.
  • Multivariate analysis identified corticosteroid dose and duration as primary risk factors; total body irradiation was not significant.

Conclusions:

  • PSC after BMT is infrequent and rarely necessitates surgical intervention.
  • High cumulative corticosteroid dose and prolonged duration are significant risk factors for PSC.
  • Total body irradiation is not a significant risk factor for PSC post-BMT.