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Parallel induction of nitric oxide and glucose-6-phosphate dehydrogenase in activated bone marrow derived macrophages
I M Corraliza1, M L Campo, J M Fuentes
1Departamento de Bioquímica, Facultad de Veterinaria, Universidad de Extremadura, Cáceres, Spain.
Biochemical and Biophysical Research Communications
|October 15, 1993
Abstract:
The production of nitric oxide (NO.) and the induction of glucose-6-phosphate dehydrogenase by lipopolysaccharides (LPS) from different sources was studied in bone marrow derived macrophages (BMM phi). NO. production was found to be linked to the induction of glucose-6-phosphate dehydrogenase, suggesting the possible involvement of this enzyme in the cytotoxic mechanism resulting from the release of NO. by activated macrophages.