An immunologist's look at the Rho and Rab GTP-binding proteins

The ras superfamily of small GTP-binding proteins contains three major branches: the Ras, Rho and Rab protein subfamilies. Recent advances in the field of ras-related small GTP-binding proteins suggest that it may be worthwhile to look at this superfamily from the standpoint of immunology. The subject of this review is to outline briefly the areas of lymphocyte function which may implicate small G proteins, with special emphasis on the established or possible roles of proteins of the Rho and Rab subfamilies in cytoskeleton organization and antigen presentation.