Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Type II citrullinemia triggered by acetaminophen]

N Shiohama1, Y Sugita, N Imamura

  • 1Department of Neurology, Kohnodai Hospital, Chiba, Japan.

No to Shinkei = Brain and Nerve
|September 1, 1993
PubMed
Summary

Acetaminophen can trigger type II citrullinemia, a urea cycle disorder, in susceptible individuals. Early diagnosis and avoiding triggers like drugs are crucial for managing this condition.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Increased Survival Benefit of Adjuvant Intra-arterial Infusion Chemotherapy in HCC Patients with Portal Vein Infiltration after Hepatectomy.

World journal of surgery·2020
Same author

Survival of T- and B-Phenotype Diffuse Aggressive Non-Hodgkin's Lymphomas.

Leukemia & lymphoma·2016
Same author

Aggressive Diffuse Lymphoma Coexpressing NRAS p21 and C-erbB-2 (neu) Oncogene Products, and CALL A (CD 10).

Leukemia & lymphoma·2016
Same author

Patterns of hematological malignancies in Chernobyl clean-up workers (1996-2005).

Experimental oncology·2006
Same author

Genetic evidence of "American" and "European" type symbiotic algae of Paramecium bursaria Ehrenberg.

Plant biology (Stuttgart, Germany)·2005
Same author

Phylogenetic position of endosymbiotic green algae in Paramecium bursaria Ehrenberg from Japan.

Plant biology (Stuttgart, Germany)·2004

Area of Science:

  • Biochemistry
  • Genetics
  • Pediatrics

Background:

  • Type II citrullinemia is a rare urea cycle disorder characterized by a deficiency in argininosuccinate synthetase.
  • This deficiency leads to hyperammonemia and potential neurological complications.

Observation:

  • A 19-year-old male presented with impaired consciousness and abnormal behaviors, diagnosed with type II citrullinemia.
  • Acetaminophen administration during a cold was identified as a probable trigger for the acute episode.
  • Clinical findings included coma, respiratory alkalosis, brain edema, and elevated plasma citrulline levels.

Findings:

  • Liver biopsy confirmed reduced argininosuccinate synthetase activity and inflammatory changes, possibly drug-induced.
  • Treatment with branched-chain amino acids improved consciousness, while sodium benzoate managed hyperammonemia.
  • A literature review identified stress, liver dysfunction, alcohol, and drugs as common triggers for type II citrullinemia.

Implications:

  • Identifying and avoiding specific triggers, such as acetaminophen, is vital for patients with type II citrullinemia.
  • Early diagnosis and prompt management are essential for improving patient outcomes and quality of life.
  • This case highlights the importance of considering drug-induced metabolic decompensation in urea cycle disorders.

Related Experiment Videos