Related Experiment Videos
Extramedullary plasmacytoma: cytological and genotypic studies
T Tamamori1, F Nakayama, H Sugimoto
1Department of Dermatology, Hamamatsu University School of Medicine, Japan.
The British Journal of Dermatology
|October 1, 1993
Summary
This study details a rare case of multiple extramedullary plasmacytomas in the skin and lymph nodes. The findings help differentiate this condition from multiple myeloma and solitary plasmacytomas.
Area of Science:
- Hematology
- Oncology
- Dermatology
Background:
- Extramedullary plasmacytomas can occur as solitary or multiple lesions.
- Distinguishing multiple cutaneous extramedullary plasmacytomas from multiple myeloma with cutaneous involvement is clinically important.
Observation:
- A 62-year-old woman presented with multiple cutaneous and lymph node plasmacytomas.
- Infiltrating cells expressed cytoplasmic IgG (lambda) and CD38, lacking B-cell markers.
- No evidence of visceral or bone marrow involvement typical of multiple myeloma was found.
Findings:
- Immunoglobulin gene rearrangement was detected in cutaneous lesions, confirming a plasma cell origin.
- The patient did not have Bence-Jones protein or a monoclonal serum immunoglobulin peak.
- The case presented unique cytological and clinical features distinct from other plasma cell neoplasms.
Implications:
- This case highlights the importance of thorough diagnostic evaluation for extramedullary plasmacytomas.
- Understanding these distinctions is crucial for appropriate patient management and prognosis.
- Further research may elucidate the specific pathogenesis of multiple cutaneous extramedullary plasmacytomas.