Related Experiment Video
Updated: Aug 7, 2026

Turbidimetry on Human Washed Platelets: The Effect of the Pannexin1-inhibitor Brilliant Blue FCF on Collagen-induced Aggregation
Published on: April 6, 2017
Lupus anticoagulant testing: effect of the platelet count on the activated partial thromboplastin time
W F Brien1, M R Schaus, K E Cooper
1Department of Clinical Laboratory Medicine, St. Joseph's Health Centre, London, Ontario, Canada.
Abstract:
The activated partial thromboplastin time (APTT) is often used as a test to diagnose patients with lupus anticoagulants. It is recommended that platelet-poor plasma be used in the APTT test. In this study the effects of residual platelet contamination on lupus anticoagulant and antiphospholipid antibody testing are described. In fresh samples the residual platelet contamination has no significant effect whereas in frozen samples the effect of residual platelet contamination can have a significant effect on the APTT testing.
Related Concept Videos
Anticoagulant Drugs: Low-Molecular-Weight Heparins
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

