[Essentiale as an inducer of immunomodulating properties in erythrocytes]

The erythrocytes extracorporeally treated with essentiale have a property to stimulate an immune response to T-dependent antigen, but fail to affect the extent of the immune response induced by T-independent antigen. The treatment of essentiale induces the appearance of immunostimulating properties in a fraction of heavy (over 1.117) erythrocytes, but does not influence the properties of light (under 1.079) and intermediate (1.092-1.105) erythrocytes. The essentiale-modified heavy erythrocytes induce intact rat splenic cell adherent to the glass to release the factor that stimulates an immune response to T-dependent antigen and the factor that induces the appearance of immunosuppressor properties of light erythrocytes.