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[Hydroelectrolyte, acid-base, and renal function changes in patients with acquired immunodeficiency syndrome]
R C Manfro1, A G Stumpf, C L Horn
1Serviço de Nefrologia, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul.
Revista Da Associacao Medica Brasileira (1992)
|January 1, 1993
Summary
Metabolic and renal disturbances are common in Acquired Immunodeficiency Syndrome (AIDS) patients. Hypokalemia, metabolic acidosis, and renal failure significantly increase mortality risk in AIDS.
Area of Science:
- Internal Medicine
- Nephrology
- Infectious Diseases
Context:
- Acquired Immunodeficiency Syndrome (AIDS) is associated with various metabolic and renal issues.
- The impact of these disturbances on patient outcomes was previously unreported.
- This study investigates the prevalence and clinical significance of these abnormalities in AIDS patients.
Purpose:
- To determine the prevalence of fluid and electrolyte, acid-base, and renal function disturbances in hospitalized AIDS patients.
- To evaluate the association between these disturbances and clinical outcomes, specifically mortality.
Summary:
- A review of 99 hospitalized AIDS patients revealed high prevalence rates: hyponatremia (45% admission, 80.7% hospitalization), hypokalemia (23.1%), metabolic acidosis (20.1%), and renal failure (28.4%).
- The study found significant associations between specific disturbances and mortality.
- Relative risks for mortality were elevated for hypokalemia (4.4), metabolic acidosis (12.9), and acute renal failure (21.4).
Impact:
- Findings highlight the high prevalence of metabolic and renal disturbances in AIDS patients.
- The study establishes a significant link between hypokalemia, metabolic acidosis, renal failure, and increased mortality in this population.
- These results underscore the importance of monitoring and managing these complications to improve clinical outcomes in AIDS care.