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Phenotypic alteration of glioma cells during culture
F Imai1, T Marunouchi, Y Mizoguchi
1Department of Neurosurgery, School of Medicine, Fujita Health University.
Noshuyo Byori = Brain Tumor Pathology
|January 1, 1993
Abstract:
Tissue specimens and culture cells from three human gliomas (two astrocytomas and one glioblastoma) were immunohistochemically investigated, using GFAP, S-100P, vimentin, FN and TNF antibodies. Primary culture consisted of two cell types, flat cells and fibrous cells. Phenotypic alternation was observed during successive subculture. Differences between fibrous cells in astrocytoma and those in glioblastoma were remarkable, while flat cells in astrocytoma and glioblastoma examined in this study, were similar.