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Updated: Aug 10, 2026

The Forced Swim Test as a Model of Depressive-like Behavior
Published on: March 2, 2015
[Imitation and utilization behavior in major depressive states]
1Service de Psychiatrie, hôpital de La Salpêtrière, Paris.
Abstract:
Imitation and utilization behaviour (IB ; UB) have been described in lesions or deafferentations of the frontal lobes. Both reflect a loss of the patients' autonomy. IB and UB having been encountered in a case of melancholia, a systematic study has been undertaken in psychiatric departments. Sixty patients have been examined among whom 18 had a major depressive episode and 19 a dysthymic episode. IB or UB or both were present in every case of the first group, in 3 cases of the second one. Such data show first an unexpected focal specific neurological sign in a psychiatric disease. Second, they suggest a relationship with the frontal hypoactivity shown by PET studies in major depressive episodes. Such frontal hypoactivity should not be viewed as the cause of major depression but as a concomitant disorder. Its role in the awareness and expression of the thymic disturbance is discussed.
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