[The study on prethrombotic state in patients with chronic obstructive pulmonary disease and cor pulmonale]

We measured PT, TT, KPTT, Fg, vWF, AT-IIIAg, AT-IIIA, alpha 2M, TXB2, 6-keto-PGF1 alpha, PLg, tPAAg, tPAA and PAI of patients with acute onset of chronic bronchitis, pulmonary emphysema, and cor pulmonale. The results were that many above parameter had a worsening tendency along with deterioration of COPD, and Fg, vWF, TXB2, 6-keto-PGF1 alpha, tPAA and PAI were more sensitive than others. The analysis of multiple liner regression of 22 blood items in patients with cor pulmonale showed that pH, PaO2, PaCO2 had correlation with many items of prethrombotic state. We consider that in the progress of COPD, prethrombotic state gradually appeared and aggravated. The causes may be related with repeatedly infections, low O2, high CO2 and imbalance of acid-base equilibrium.