Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Resistance to thyroid hormone

S Refetoff1

  • 1Department of Medicine, University of Chicago, Illinois.

Clinics in Laboratory Medicine
|September 1, 1993
PubMed
Summary
This summary is machine-generated.

Resistance to thyroid hormone (RTH) involves reduced tissue response to thyroid hormone. Diagnosis requires elevated thyroid hormone with nonsuppressed TSH, and lack of response to hormone replacement therapy.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical recognition and evaluation of patients with inherited serum thyroid hormone-binding protein mutations.

Journal of endocrinological investigation·2019
Same author

INSUFFICIENCY OF LEVOTHYROXINE THERAPY IN AUTOIMMUNE HYPOTHYROIDISM: EFFECT OF GLUCOCORTICOID ADMINISTRATION.

Acta endocrinologica (Bucharest, Romania : 2005)·2019
Same author

A novel mutation in the TG gene (G2322S) causing congenital hypothyroidism in a Sudanese family: a case report.

BMC medical genetics·2018
Same author

Hematopoietic Stem Cells Transplantation Can Normalize Thyroid Function in a Cystinosis Mouse Model.

Endocrinology·2016
Same author

A mouse model suggests two mechanisms for thyroid alterations in infantile cystinosis: decreased thyroglobulin synthesis due to endoplasmic reticulum stress/unfolded protein response and impaired lysosomal processing.

Endocrinology·2015
Same author

Inherited defects of thyroid hormone metabolism.

Annales d'endocrinologie·2011
Same journal

Advances in Hemostasis Laboratory Testing.

Clinics in laboratory medicine·2026
Same journal

Extracellular Vesicles in Hemostasis.

Clinics in laboratory medicine·2026
Same journal

Thrombin Generation Assay: Ready for Prime Time.

Clinics in laboratory medicine·2026
Same journal

Viscoelastic Testing for the Laboratorian: Recent Advances and Practical Advice.

Clinics in laboratory medicine·2026
Same journal

Practical Recommendations for Harmonization of Hemostasis Testing Across Hospital Sites.

Clinics in laboratory medicine·2026
Same journal

The Role of Hypoxia in Vascular Endothelial Dysfunction and Venous Thromboembolism.

Clinics in laboratory medicine·2026
See all related articles

Area of Science:

  • Endocrinology
  • Molecular Genetics
  • Internal Medicine

Background:

  • Resistance to thyroid hormone (RTH) is a rare genetic disorder.
  • Characterized by impaired thyroid hormone action in target tissues.
  • Leads to elevated thyroid hormone levels with normal or elevated TSH.

Purpose of the Study:

  • To define the diagnostic criteria for RTH.
  • To outline the clinical and biochemical features of RTH.
  • To differentiate RTH from other thyroid disorders.

Main Methods:

  • Biochemical assays for thyroid hormones and TSH.
  • Assessment of TSH suppression by thyroid hormone administration.
  • Clinical evaluation of peripheral tissue responses.

Related Experiment Videos

Main Results:

  • Elevated free thyroid hormones (T4 and T3) with unsuppressed TSH are key indicators.
  • Lack of TSH suppression after thyroid hormone administration confirms the diagnosis.
  • Variable clinical manifestations across different tissues.

Conclusions:

  • RTH diagnosis relies on specific biochemical and physiological criteria.
  • Confirms the heterogeneous nature of RTH.
  • Highlights the importance of functional testing for accurate diagnosis.