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Cardiac performance and thyroid function. The correlation between systolic time intervals, heart rate and thyroid
A M Galløe1, M Rolff, H Nordin
1Medical Department P/Chest Clinic, Bispebjerg Hospital, Copenhagen.
Danish Medical Bulletin
|September 1, 1993
Summary
Thyroid function significantly impacts cardiac function, showing a curvilinear relationship with systolic time intervals and an almost linear one with heart rate. However, heart rate variations are too large to serve as a reliable clinical correlate for thyroid status.
Area of Science:
- Endocrinology
- Cardiology
Background:
- Thyroid hormones play a crucial role in regulating cardiac function.
- Assessing cardiac function through heart rate and systolic time intervals can provide insights into thyroid status.
Purpose of the Study:
- To investigate the correlation between plasma thyroid hormone levels and cardiac function parameters.
- To explore the use of curvilinear regression for analyzing this relationship across the entire hormone range.
Main Methods:
- Utilized a third-degree Chebyshev regression equation for curvilinear correlation analysis.
- Examined a cohort comprising hypothyroid, euthyroid, and hyperthyroid patients.
- Assessed cardiac function via heart rate and systolic time intervals.
Main Results:
- A statistically significant curvilinear correlation was observed between thyroid hormone levels and systolic time intervals.
- Heart rate demonstrated a correlation comparable to the best-correlated systolic time intervals.
- The relationship between heart rate and triiodothyronine (T3) was nearly linear, with a 4 beats/minute increase per 1 nmol/l T3 rise.
Conclusions:
- Thyroid function is reflected in cardiac function through curvilinear regression with systolic time intervals and near-linear regression with heart rate.
- Despite significant correlations, the variability and low slope of heart rate changes preclude its use as a precise clinical correlate for thyroid function.