[Aggressive fibromatosis of bone]

Area of Science:

• Orthopedic Oncology
• Surgical Pathology
• Bone Tumors

Context:

• Aggressive fibromatosis of bone, a rare neoplastic proliferation, presents diagnostic and prognostic challenges.
• Distinguishing benign recurrence from malignant transformation is critical for patient management.

Purpose:

• To analyze the clinical course and histological features of aggressive fibromatosis of bone.
• To establish diagnostic criteria for aggressive fibromatosis of bone, focusing on recurrence and metastatic potential.

Summary:

• Twenty-four cases of aggressive fibromatosis of bone were reviewed, with 17 patients followed for over two years.
• Recurrence was observed in 4 patients, with benign histological findings persisting post-recurrence.
• One case showed no malignant changes after 3.5 years without radical treatment, while another experienced fatal lung metastasis.

Impact:

• Proposed diagnostic criteria include benign histological features and no recurrence or metastasis beyond two years post-operation.
• Recommends marginal or wide excision as the primary surgical treatment modality.
• Highlights the importance of long-term follow-up to accurately diagnose and manage aggressive fibromatosis of bone.