[The effect of indapamide on phosphate metabolism in hypertensive patients]

Twenty-four patients were studied to assess the efficacy and principle of indapamide in hypertensive patients previously treated and unsatisfactorily controlled with either angiotensin-converting enzyme (ACE) inhibitor or atenolol therapy. The result showed a satisfactory anti-hypertensive effect of indapamide. Plasma phosphate concentrations were markedly reduced and no significant variance in plasma K+, Na+ and Ca+ concentration after two weeks of indapamide therapy (2.5 mg, one day). Thus indapamideinduced reduction of blood pressure could be mediated by an effect of this drug on phosphate balance.