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Interactions between active-site serine beta-lactamases and so-called beta-lactamase-stable antibiotics. Kinetic and
A Matagne1, J Lamotte-Brasseur, J M Frère
1Laboratoire d'Enzymologie, Université de Liège, Belgium.
European Journal of Biochemistry
|October 1, 1993
Abstract:
The interactions between imipenem and four monobactams and three class A beta-lactamases have been studied in detail. Despite their reputation as being beta-lactamase-stable, some of these compounds were significantly hydrolysed by the enzymes. The results obtained with the Streptomyces albus G beta-lactamase have been analysed in the light of molecular modelling studies. The discussion is extended to include other so-called beta-lactamase-stable antibiotics to demonstrate that this appellation can often be misleading.