Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ventilatory pattern during bronchial histamine challenge in asthmatics

N O Strömberg1, P M Gustafsson

  • 1Dept of Pediatrics, Faculty of Health Sciences, University Hospital, Linköping, Sweden.

The European Respiratory Journal
|September 1, 1993
PubMed
Summary

Asthmatic teenagers did not consistently alter their breathing patterns during histamine challenges, even with significant lung function decline. Therefore, respiratory pattern analysis is not a reliable method for monitoring airway obstruction continuously.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Novel methodology to perform sulfur hexafluoride (SF6)-based multiple-breath wash-in and washout in infants using current commercially available equipment.

Journal of applied physiology (Bethesda, Md. : 1985)·2016
Same author

Asthma phenotypes and lung function up to 16 years of age-the BAMSE cohort.

Allergy·2015
Same author

Slow and fast lung compartments in cystic fibrosis measured by nitrogen multiple-breath washout.

Journal of applied physiology (Bethesda, Md. : 1985)·2014
Same author

Comparison of the utility of multiple breath inert gas washout parameters in cystic fibrosis.

Thorax·2010
Same author

Lung clearance index is a sensitive, repeatable and practical measure of airways disease in adults with cystic fibrosis.

Thorax·2007
Same author

Multiple-breath inert gas washout and spirometry versus structural lung disease in cystic fibrosis.

Thorax·2007

Area of Science:

  • Pulmonary Physiology
  • Respiratory Medicine

Background:

  • Asthma management requires continuous monitoring of bronchial obstruction.
  • Assessing changes in ventilatory patterns could offer a non-invasive method for this monitoring.

Purpose of the Study:

  • To investigate if asthmatic subjects consistently change their ventilatory patterns during bronchial histamine challenge when forced expiratory volume in one second (FEV1) declines by at least 20%.
  • To determine the feasibility of using respiratory pattern analysis for continuous monitoring of bronchial obstruction.

Main Methods:

  • Eight asthmatic teenagers underwent two histamine challenges within four weeks.
  • Respiratory inductive plethysmography (RIP) evaluated respiratory patterns during natural breathing and breathing through a pneumo-tachometer (PTM) with a noseclip.

Related Experiment Videos

  • End-tidal carbon dioxide tension (PETCO2) was measured.

    • Main Results:

    • Four of eight patients showed hyperventilation (increased minute ventilation and inspiratory flow, decreased PETCO2) during natural breathing.
    • Ventilatory and FEV1 responses did not differ between responders and non-responders.
    • The ventilatory response to histamine was abolished when breathing through a PTM.

    Conclusions:

    • Histamine-induced bronchospasm is not uniformly reflected in breathing patterns.
    • Hyperventilation may result from vagal airway receptor activation.
    • Respiratory pattern analysis is not a feasible method to monitor bronchial obstruction during histamine challenge.