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Published on: October 26, 2017
A comment on the absence of calcium regulation of human thioredoxin reductase
1Arizona Cancer Center, Tucson 85715.
Abstract:
It has been previously suggested that human thioredoxin reductase activity is regulated by calcium. However, the activity of a purified form of human placental thioredoxin reductase was found to not be affected by mM concentrations of calcium, well above intra- and extracellular physiological levels. Furthermore, the suggestion that an E-F hand is present in Escherichia coli thioredoxin reductase is strongly contested. These current results suggest that human thioredoxin reductase is not regulated by calcium.
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