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Gram-hegative bacillemia

M C McHenry, W A Hawk, R A Straffon

    The Urologic Clinics of North America
    |June 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Gram-negative bacillemia is increasingly common, with the Klebsiella-Enterobacter-Serratia group being the most frequent cause. Prompt, presumptive antimicrobial treatment based on infection site and clinical clues improves outcomes for this serious condition.

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    Area of Science:

    • Infectious Diseases
    • Microbiology
    • Clinical Medicine

    Background:

    • Gram-negative bacillemia is a significant cause of mortality.
    • The Klebsiella-Enterobacter-Serratia group is now the most common cause, surpassing E. coli.
    • While urinary tract infections remain a common source, extraurinary lesions are increasingly important.

    Purpose of the Study:

    • To review the epidemiology and management of gram-negative bacillemia.
    • To highlight the importance of presumptive etiologic diagnosis and prompt antimicrobial therapy.
    • To demonstrate the reduction in mortality through a rational approach to treatment.

    Main Methods:

    • Review of current literature on gram-negative bacillemia.
    • Analysis of causative organisms and infection sources.

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  • Evaluation of treatment strategies based on presumptive diagnosis.

    • Main Results:

    • Klebsiella-Enterobacter-Serratia group is the leading cause of gram-negative bacillemia.
    • E. coli remains the primary cause of urinary tract-related bacteremia.
    • Severity of underlying disease and infection significantly impacts patient outcomes.

    Conclusions:

    • Prompt, decisive action and presumptive antimicrobial therapy are crucial for managing gram-negative bacillemia.
    • Knowledge of likely pathogens and effective antimicrobials guides initial treatment.
    • This approach has significantly reduced mortality, particularly for urinary tract-related cases.