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Related Experiment Videos

Effect of fluvoxamine on panic disorder

R Hoehn-Saric1, D R McLeod, P A Hipsley

  • 1Department of Psychiatry and Behavioral Sciences, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287-7144.

Journal of Clinical Psychopharmacology
|October 1, 1993
PubMed
Summary

Fluvoxamine significantly reduced panic attack frequency and severity in patients with panic disorder. This selective serotonin reuptake inhibitor also improved anxiety, depression, and disability over placebo.

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Area of Science:

  • Psychiatry
  • Pharmacology
  • Clinical Psychology

Background:

  • Panic disorder is a debilitating condition.
  • Selective serotonin reuptake inhibitors (SSRIs) are frequently used for treatment.
  • Fluvoxamine is an SSRI with potential anxiolytic and antidepressant effects.

Purpose of the Study:

  • To compare the efficacy of fluvoxamine versus placebo in treating panic disorder.
  • To assess the impact of fluvoxamine on panic attack frequency, severity, anxiety, depression, and disability.

Main Methods:

  • An 8-week, double-blind, parallel-groups study.
  • Involved 50 patients diagnosed with panic disorder.
  • Utilized weekly assessments including panic attack diaries, Montgomery-Asberg Depression Scale, Clinical Anxiety Scale, and Sheehan Disability Scale.

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Main Results:

  • Fluvoxamine significantly reduced the frequency of major panic attacks starting from week 3.
  • Significant improvements in anxiety, depression, and disability were observed in the fluvoxamine group from week 6.
  • No significant difference was found in the severity of panic attacks between fluvoxamine and placebo.
  • More patients receiving fluvoxamine were free from both major and minor panic attacks by study end.

Conclusions:

  • Fluvoxamine is effective in reducing panic attack frequency in patients with panic disorder.
  • While panic attack severity was not affected, fluvoxamine improved associated anxiety, depressive mood, and disability.
  • The study highlights the therapeutic potential of fluvoxamine in managing panic disorder symptoms.