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Theophylline toxicity from an over-the-counter preparation
D R Bahner1, M L Frenia, W L Augenstein
1Division of Emergency Medicine, University of Florida Health Science Center/Jacksonville 32209.
The Journal of Emergency Medicine
|July 1, 1993
Summary
Theophylline toxicity can occur from over-the-counter (OTC) medications, not just prescription drugs. Accidental or intentional overdose from these widely available products can lead to severe health issues.
Area of Science:
- Pharmacology
- Clinical Toxicology
Background:
- Theophylline is a medication with a narrow therapeutic index, increasing the risk of toxicity.
- Clinical presentations of theophylline poisoning include severe cardiac, neurologic, and gastrointestinal manifestations.
- Theophylline toxicity can result from intentional overdose, accidental ingestion, or iatrogenic causes.
Observation:
- A case of theophylline toxicity was identified originating from an over-the-counter (OTC) combination product.
- This nonprescription product contained theophylline, ephedrine, and phenobarbital.
- The availability of theophylline in OTC formulations is not widely recognized.
Findings:
- Theophylline toxicity from OTC products poses a significant risk.
- Combination products containing theophylline can lead to severe adverse events.
- Clinicians must consider OTC medications as a potential source of theophylline poisoning.
Implications:
- Healthcare providers should educate patients about the risks associated with OTC medications containing theophylline.
- Increased awareness among clinicians regarding theophylline in nonprescription drugs is crucial for patient safety.
- Regulatory bodies may need to review the accessibility of such combination products.