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First-phase insulin release in normal children

H F Allen1, B W Jeffers, G J Klingensmith

  • 1Department of Pediatrics, University of Colorado Health Sciences Center, Denver 80262.

The Journal of Pediatrics
|November 1, 1993
PubMed
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First-phase insulin release is lower in children than adolescents. This study defines normal values for first-phase insulin release during an intravenous glucose tolerance test in healthy youth.

Area of Science:

  • Pediatrics
  • Endocrinology
  • Metabolic Research

Background:

  • Normal values for first-phase insulin release (FPIR) in youth are not well-established.
  • Understanding FPIR is crucial for assessing pancreatic beta-cell function.
  • Variations in FPIR can indicate underlying metabolic or endocrine conditions.

Purpose of the Study:

  • To define normal ranges for FPIR during an intravenous glucose tolerance test (IVGTT) in healthy children and adolescents.
  • To investigate the relationship between age, pubertal status, and FPIR.
  • To assess the impact of acute stress on FPIR.

Main Methods:

  • A standard intravenous glucose tolerance test (IVGTT) was administered to 69 healthy subjects aged 7 to 22 years.
  • Subjects were screened for family history of type I diabetes, normal glycohemoglobin, and negative islet cell antibodies.

Related Experiment Videos

  • FPIR was measured, and intraindividual variability was assessed in a subset of subjects.

    • Main Results:

    • Mean FPIR significantly increased with age and pubertal status.
    • FPIR values were 93 +/- 10.1 mIU/L (7-10 years), 172.7 +/- 22.3 mIU/L (11-15 years), and 163 +/- 28.5 mIU/L (16-22 years).
    • Acute stress did not show a significant correlation with FPIR.

    Conclusions:

    • First-phase insulin release is markedly lower in prepubertal children compared to adolescents and young adults.
    • Age and pubertal status are key determinants of normal FPIR values in youth.
    • These findings provide essential reference ranges for pediatric endocrinology and diabetes research.