Related Experiment Video

Updated: Aug 16, 2026

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
05:31

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Published on: August 7, 2017

Vitamin A levels and feeding practice in neonates with and without chronic lung disease

V Chan1, A Greenough, P Cheeseman

  • 1Department of Child Health, King's College Hospital, London, U.K.

Journal of Perinatal Medicine
|January 1, 1993
PubMed

Insights

Preterm infants with chronic lung disease (CLD) show low vitamin A levels. Feeding practices significantly impact vitamin A levels, suggesting a link between nutrition and CLD in neonates.

Area of Science:

  • Neonatology
  • Nutritional Science
  • Pediatric Pulmonology

Background:

  • Infants with chronic lung disease (CLD) exhibit lower vitamin A levels.
  • Vitamin A deficiency is a concern in preterm infants.

Purpose of the Study:

  • To investigate factors influencing the association between CLD and low vitamin A levels in preterm infants.
  • To assess the role of feeding practices in this relationship.

Main Methods:

  • Determined vitamin A levels in preterm infants (<32 weeks gestational age) with and without CLD.
  • Correlated vitamin A levels with feeding practices, mechanical ventilation, and parenteral nutrition duration.

Main Results:

  • Infants with CLD had significantly lower vitamin A levels from day 21 onwards.
  • Median vitamin A levels in infants with CLD were below 60% of the minimum acceptable level after day 11.
  • Infants with CLD required longer mechanical ventilation and parenteral nutrition, with a strong positive correlation between these durations (r = 0.83).
  • Infants with CLD received less vitamin A supplementation compared to controls.

Conclusions:

  • Feeding practices appear to be a key factor explaining the association between CLD and vitamin A deficiency in preterm infants.
  • Optimizing vitamin A supplementation and nutritional support is crucial for infants with CLD.

More Related Videos

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs08:58

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs

Published on: October 31, 2025

Isolation of Lung Retinoid-Containing Cells by Cell Sorting07:47

Isolation of Lung Retinoid-Containing Cells by Cell Sorting

Published on: April 11, 2025

Related Concept Videos

Respiratory Assessment: Purpose and Indications01:19

Respiratory Assessment: Purpose and Indications

Respiratory assessment is a cornerstone of nursing assessments, crucial for the early detection of patient deterioration. This evaluation transcends routine procedures, representing a critical skill nurses must master to ensure optimal patient care.
Objectives and Importance:
The primary goal of respiratory assessment is to evaluate patients at early risk of clinical deterioration. Since respiratory distress often precedes other signs of declining health, breathing patterns and sounds become a...
Assessment of Airway, Skin Color, and Use of Accessory Muscles01:30

Assessment of Airway, Skin Color, and Use of Accessory Muscles

A thorough assessment of respiratory health is paramount in clinical settings to identify and manage respiratory distress and ensure adequate oxygenation. This article elaborates on the critical aspects of respiratory evaluation, including airway assessment, skin color examination, and the observation of accessory muscle use, which are integral to effectively diagnosing and managing patients with respiratory conditions.
Introduction
The initial evaluation of a patient's respiratory system...
Pneumonia V: Nursing management and Prevention01:30

Pneumonia V: Nursing management and Prevention

Nursing management of pneumonia involves promoting airway patency, facilitating rest and conserving energy, encouraging fluid intake, maintaining nutrition, and educating patients.
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed.
Acute Respiratory Failure-V01:29

Acute Respiratory Failure-V

The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
Ensure that patients are monitored continuously for their response to therapy, including changes in...