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Dermic peripheral microangiopathy in plasmo-proliferative disorders

E F Valdés, M V Herrero, I Calb

    Dermatologica
    |January 1, 1976
    PubMed
    Summary

    Skin biopsies from patients with plasmo-proliferative diseases revealed dermal microvascular damage, including thickened basal membranes and endothelial proliferation. These findings highlight potential microcirculation issues in immunologic malignant disorders.

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    Area of Science:

    • Dermatology
    • Hematology
    • Pathology

    Background:

    • Plasmo-proliferative diseases, such as myeloma and macroglobulinemia, can affect various organ systems.
    • Microvascular alterations are increasingly recognized as a component of systemic diseases.

    Purpose of the Study:

    • To investigate histopathological and histochemical changes in dermal microvasculature of patients with plasmo-proliferative diseases.
    • To compare these changes with other microangiopathies and identify potential pathogenic mechanisms.

    Main Methods:

    • Histopathological and histochemical examination of skin biopsy specimens from 12 patients.
    • Morphological analysis of dermal microvasculature, including basal membrane and endothelial cells.
    • Assessment of blood coagulation, carbohydrate metabolism, serum hyperviscosity, and cryoglobulinemia.

    Main Results:

    • All patients exhibited dermal microvascular alterations: thickened PAS-stained basal membrane, endothelial swelling, and proliferation leading to partial lumen obliteration.
    • Lesions were similar to diabetic and paralymphomatous microangiopathy, but with more pronounced endothelial proliferation.
    • No lesions were observed in healthy controls.
    • Normal blood coagulation and carbohydrate metabolism; serum hyperviscosity was present in all patients, with cryoglobulinemia in three.

    Conclusions:

    • Dermal microvascular lesions are characteristic of plasmo-proliferative diseases.
    • Endothelial proliferation is a prominent feature, distinguishing these lesions from other microangiopathies.
    • Further research is needed to elucidate the pathogenic and biological aspects of these microvascular changes in immunologic malignant disorders.

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