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[Bullous amyloidosis]

T Kanoh1

  • 1Department of Internal Medicine, Faculty of Medicine, Kyoto University.

[Rinsho Ketsueki] the Japanese Journal of Clinical Hematology
|September 1, 1993
PubMed
Summary
This summary is machine-generated.

Bullous amyloid lesions, though rare, can signal plasma cell dyscrasia. This case highlights their link to multiple myeloma and systemic amyloidosis, leading to fatal renal failure.

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Area of Science:

  • Hematology
  • Dermatology
  • Nephrology

Background:

  • Plasma cell dyscrasias, such as multiple myeloma, can manifest with rare cutaneous lesions.
  • Amyloidosis is a condition characterized by the deposition of amyloid protein in various organs.

Observation:

  • A 66-year-old male with a history of multiple myeloma presented with hemorrhagic bullous skin lesions, chronic diarrhea, and malaise.
  • The patient was diagnosed with myeloma-associated amyloidosis complicated by renal failure.

Findings:

  • Histologic examination of the bullous lesions revealed intradermal amyloid deposits.
  • Postmortem examination confirmed widespread amyloid deposition in multiple organs, including skin, heart, lungs, kidneys, liver, and intestine, alongside myelomatous infiltrations.

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Implications:

  • Bullous amyloid lesions serve as a critical, albeit rare, cutaneous indicator of underlying plasma cell dyscrasias.
  • This case underscores the aggressive nature of systemic amyloidosis secondary to multiple myeloma and its potential for rapid progression to fatal renal failure.