Intraglomerular lipid deposition in renal disease

Lipid abnormalities are seen as important modulators of progressive renal disease. In most human glomerular diseases, localized accumulations of apolipoprotein (Apo) B- or Apo E-containing lipoproteins have been found in nonsclerotic glomeruli. Intraglomerular lipid deposition occurs in structurally damaged glomeruli, except for rare cases of dyslipoproteinemias. Studies of cases with lipid deposition in nonsclerotic glomeruli might provide important insights into the connection between lipids and the progression of original glomerular injury.