Related Experiment Videos
The subthalamic nucleus: a possible target for stereotaxic surgery in Parkinson's disease
J Guridi1, M R Luquin, M T Herrero
1Movement Disorders Unit, Clinica Universitaria, Pamplona, Spain.
Abstract:
Hyperactivity in the subthalamic nucleus (STN) projections to the globus pallidus medialis (GPM) has been established as a crucial feature of parkinsonism in animal models of Parkinson's disease (PD). Recent experiments blocking the STN glutamatergic output to GPM or lesioning the STN support this concept by showing a dramatic reversal of parkinsonism. We review the role of stereotaxic surgery in the past and the possible future application of subthalamotomy for PD.