[Course of bacterial infections in high-dose therapy with clozapine]

The influence of neuroleptic drugs on body temperature regulation is well established. Even with atypical neuroleptic drugs such as clozapine, hyperthermia has been observed as well as the malignant neuroleptic syndrome. It is likely that the influence of clozapine affects the immune response. A case is reported in which afebrile angina tonsillaris and endocarditis developed, as a result of high-dosage therapy with clozapine over several years. Besides the special features of the course, differential diagnosis, therapy and possible influence on the body temperature and the immune response are discussed.