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Ototoxicity of topical agents
G N Rohn1, W L Meyerhoff, C G Wright
1Department of Otorhinolaryngology, University of Texas Southwestern Medical Center, Dallas.
Abstract:
Topical otic preparations are commonly prescribed by otolaryngologists--head and neck surgeons. It is well documented in the literature that some agents in these preparations are ototoxic when applied to the middle ear in experimental animals, although the occurrence of ototoxicity in the clinical setting is controversial. This article discusses topical otic preparations currently available as well as various other agents. The clinician should prescribe these preparations with close surveillance for potential ototoxicity.
Insights
Topical otic preparations can cause hearing damage (ototoxicity) in the middle ear, particularly in animal studies. Clinicians should carefully monitor patients for potential ototoxicity when prescribing these common ear medications.
Area of Science:
- Otolaryngology
- Pharmacology
- Toxicology
Background:
- Topical otic preparations are frequently prescribed by otolaryngologists--head and neck surgeons.
- The ototoxic potential of certain agents in these preparations is documented in animal models.
- Clinical evidence regarding ototoxicity from topical otic preparations remains controversial.
Purpose of the Study:
- To review currently available topical otic preparations.
- To discuss various agents used in otic preparations.
- To highlight the importance of monitoring for potential ototoxicity.
Main Methods:
- Literature review of topical otic preparations.
- Discussion of ototoxic agents.
- Clinical surveillance recommendations.
Main Results:
- Some agents in topical otic preparations have demonstrated ototoxicity in experimental animal studies.
- The clinical significance of ototoxicity from these preparations is debated.
- A range of topical otic agents and other relevant substances are discussed.
Conclusions:
- Clinicians must exercise caution when prescribing topical otic preparations.
- Close patient surveillance for signs of ototoxicity is crucial.
- Understanding the potential risks associated with otic agents is essential for safe practice.