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Particulate dermal matrix as an injectable soft tissue replacement material.

S Griffey1, N D Schwade, C G Wright

  • 1LifeCell Corporation, Branchburg, New Jersey 08876, USA. sgriffey@lifecell.com

Journal of Biomedical Materials Research
|January 12, 2001
PubMed
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This study introduces a novel injectable dermal matrix for soft tissue replacement, overcoming limitations of current materials. Processing in liquid nitrogen enhances its persistence and cellular integration for improved cosmetic and reconstructive applications.

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Tissue Engineering

Background:

  • Current injectable soft tissue fillers have limitations like reactivity, migration, and degradation.
  • Existing materials often require donor sites, increasing procedural complexity.

Purpose of the Study:

  • To evaluate the feasibility of a particulate acellular human dermal matrix as an injectable soft tissue replacement.
  • To address shortfalls associated with existing injectable materials.

Main Methods:

  • Animal feasibility studies were conducted using a rat model.
  • Investigated the impact of processing techniques (shearing vs. liquid nitrogen) on matrix integrity and performance.
  • Assessed matrix concentration and injected volume effects.

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Main Results:

  • Shearing/tearing processing led to collagen damage and rapid implant resorption.
  • Liquid nitrogen processing preserved collagen integrity, resulting in longer implant persistence.
  • The particulate matrix demonstrated rapid host cell repopulation, promoting revascularization and remodeling.
  • High concentrations (up to 330 mg/mL) are achievable, potentially reducing the need for overcorrection and repeat injections.

Conclusions:

  • Particulate acellular human dermal matrix processed in liquid nitrogen is a promising injectable soft tissue replacement.
  • This novel material offers improved persistence and integration compared to damaged matrices.
  • The high concentration capability offers clinical advantages in soft tissue augmentation.