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Updated: Aug 9, 2026

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Published on: January 13, 2017
EMLA cream, a mix of prilocaine and lidocaine, effectively numbs intact skin for procedures. Optimal pain relief requires 60 minutes of application under occlusion, limiting emergency use but benefiting planned interventions.
Area of Science:
- Dermatology
- Anesthesiology
- Pharmacology
Background:
- EMLA cream is a topical anesthetic containing prilocaine and lidocaine.
- It achieves complete anesthesia of intact skin after application.
Purpose of the Study:
- To evaluate the efficacy and application guidelines of EMLA cream for pain management in various procedures.
- To assess its utility in both anticipated and emergency situations, and across different patient populations.
Main Methods:
- Application of EMLA cream to intact skin followed by an occlusive dressing for 60 minutes prior to procedures.
- Utilized in venipuncture, lumbar punctures, and investigated for intramuscular injections and circumcision.
Main Results:
- EMLA cream provides complete skin anesthesia when applied correctly.
- Optimal effect requires a 60-minute application period with occlusion.
- Effective in children of all ages for pain relief during venipunctures and lumbar punctures.
Conclusions:
- EMLA cream is highly effective for pain management in anticipated procedures, including outpatient surgery.
- Its 60-minute application requirement limits use in emergencies.
- EMLA cream offers significant pain relief for pediatric procedures like venipuncture and lumbar puncture.
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