Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Liver involvement in systemic lupus erythematosus]

P Caramaschi1, D Biasi, M Botto

  • 1Istituto di Clinica Medica, Università, Verona.

Recenti Progressi in Medicina
|October 1, 1993
PubMed
Summary

Liver disease in systemic lupus erythematosus (SLE) is often mild, but this study found it may indicate severe disease, particularly with positive anti-ds-DNA antibodies.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Gender differences in clinical features and quality of life of patients with axial spondyloarthritis and psoriatic arthritis.

Reumatismo·2024
Same author

Secukinumab retention rate is greater in patients with psoriatic arthritis presenting with axial involvement.

Reumatismo·2023
Same author

Analysis of HLA-G expression in renal tissue in lupus nephritis: a pilot study.

Lupus·2019
Same author

A triglyceride-rich lipoprotein environment exacerbates renal injury in the accelerated nephrotoxic nephritis model.

Clinical and experimental immunology·2018
Same author

Real-world experience of tocilizumab in rheumatoid arthritis: sub-analysis of data from the Italian biologics' register GISEA.

Clinical rheumatology·2017
Same author

Plasmachemical Double Click Thiol-ene Reactions for Wet Electrical Barrier.

ACS applied materials & interfaces·2016

Area of Science:

  • Rheumatology
  • Hepatology
  • Immunology

Background:

  • Liver disease is reported in 8-23% of patients with systemic lupus erythematosus (SLE), typically with minor clinical impact.
  • This study investigated the incidence and characteristics of liver abnormalities in a cohort of 86 SLE patients.

Observation:

  • Liver involvement was defined by at least two abnormal liver function tests on separate occasions.
  • Evidence of liver disease was found in 23.2% of the SLE patients.
  • Of these, 16.2% had hepatic involvement directly attributed to SLE, while 7% had abnormalities due to other causes like drugs, infection, or fatty liver.

Findings:

  • SLE-related liver disease was significantly associated with a higher frequency of anti-ds-DNA antibodies (92.8% vs. 51.3%, p < 0.05).
  • This suggests that liver disease may be a marker for more severe SLE.

Related Experiment Videos

  • Hepatic injury as the initial clinical manifestation of SLE was rare (1 case), presenting as clinically relevant chronic active hepatitis.

    • Implications:

    • The findings suggest that unexplained liver disease in SLE patients warrants thorough investigation and may indicate a more severe disease phenotype.
    • This highlights the potential link between SLE, autoimmune hepatitis, and the presence of anti-ds-DNA antibodies.
    • Further research is needed to elucidate the precise mechanisms and clinical significance of liver involvement in SLE.