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Enhancement of bone formation in rabbits by recombinant human growth hormone
A Ehrnberg1, O Brosjö, P Låftman
1Department of Orthopedics, Karolinska Hospital, Stockholm, Sweden.
Acta Orthopaedica Scandinavica
|October 1, 1993
Abstract:
We studied the effect of human recombinant growth hormone on diaphyseal bone in 40 adult rabbits. The diaphyseal periosteum of one femur in each animal was mechanically stimulated by a nylon cerclage band. The bands induced an increase in bone formation, bone mineral content, and maximum torque capacity of the diaphyseal bone at 1 and 2 months. Growth hormone enhanced the anabolic effect of the cerclage bands on bone metabolism, evidenced by a further increase in torsional strength of the femurs.