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Euglobulin lysis times: an update

A Glassman1, M Abram, G Baxter

  • 1Department of Laboratories, Vanderbilt University Medical Center, Nashville, TN 37232.

Annals of Clinical and Laboratory Science
|September 1, 1993
PubMed
Summary
This summary is machine-generated.

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The euglobulin lysis test (ELT) measures fibrinolysis, with normal ranges varying widely. This study established a reference range for ELT in healthy adults, finding an average of 3.5 hours.

Area of Science:

  • Hematology
  • Clinical Chemistry

Background:

  • Fibrinolysis assessment involves various clot lysis tests, including the euglobulin lysis test (ELT).
  • The ELT specifically detects plasminogen activation and subsequent fibrinolysis, excluding antiplasmin activity.

Purpose of the Study:

  • To determine the euglobulin lysis time (ELT) reference range in a group of 25 healthy, ambulatory adults.
  • To investigate the effect of venostasis on ELT.

Main Methods:

  • Collected blood samples from 25 healthy adults (10 males, 15 females; age 25-56).
  • Obtained samples with and without venostasis (sphygmomanometer).
  • Precipitated plasma with acetic acid, redissolved the precipitate, clotted with thrombin, and incubated at 37°C, observing for clot lysis.

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Main Results:

  • The reference range for the onset of fibrinolysis was 1.25 to 12 hours (mean 3.78 ± 2.45 hours).
  • Venostasis shortened ELT in 11 out of 25 specimens, suggesting in vivo plasminogen activation.

Conclusions:

  • The average euglobulin lysis time in healthy ambulatory adults is approximately 3.5 hours.
  • Significant variability exists in ELT among normal individuals, with a broad range observed (1.25 to 12.0 hours).