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Continuum analysis method applied to blood count reference intervals

A Richardson-Jones1, D Twedt, M Gibson

  • 1Clinical Laboratory, Coulter Corporation, Hialeah, FL 33011.

Annals of Clinical and Laboratory Science
|September 1, 1993
PubMed
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This study proposes a new method for defining normal reference ranges by analyzing analyte dispersion. This approach refines reference ranges, potentially excluding non-normal individuals and highlighting subclinical disorders.

Area of Science:

  • Clinical Chemistry
  • Biostatistics
  • Hematology

Background:

  • Traditional reference value determination often includes non-normal individuals.
  • Existing methods can obscure marginal or subclinical disorders.
  • The dichotomous nature of current reference ranges is a limitation.

Purpose of the Study:

  • To propose a novel method for defining analyte reference ranges.
  • To improve the precision of normal range determination.
  • To address the limitations of conventional reference value extraction.

Main Methods:

  • Defining normal ranges by extrapolating the continuum portion of analyte dispersion.
  • Softening the dichotomous character of traditional reference ranges.
  • Applying the method to hematology parameters.

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Main Results:

  • The proposed method narrows the normal range for certain hematology parameters.
  • This narrowing suggests the exclusion of non-normal individuals.
  • The approach offers a more nuanced definition of the normal range.

Conclusions:

  • Extrapolating analyte dispersion provides a refined method for reference range definition.
  • This continuum-based approach improves the identification of normal physiological states.
  • The method enhances the clinical utility of reference values by excluding outliers.