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Detection and characterization of mupirocin resistance in Staphylococcus aureus
D A Janssen1, L T Zarins, D R Schaberg
1Division of Infectious Diseases, Department of Veterans Affairs Medical Center, University of Michigan Medical School, Ann Arbor 48105.
Antimicrobial Agents and Chemotherapy
|September 1, 1993
Abstract:
Fourteen mupirocin-resistant Staphylococcus aureus strains were isolated over 18 months; 12 exhibited low-level resistance, while two showed high-level resistance. Highly mupirocin-resistant strains contained a large plasmid which transferred mupirocin resistance to other S. aureus strains and to Staphylococcus epidermidis. This plasmid and pAM899-1, a self-transferable gentamicin resistance plasmid, have molecular and biologic similarities.