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The role of the immune system in establishment of herpes simplex virus latency--studies using CD4+ T-cell depleted

D S Schmidt1, A M Eis-Hübinger, K E Schneweis

  • 1Institute of Medical Microbiology and Immunology, University of Bonn, Federal Republic of Germany.

Archives of Virology
|January 1, 1993
PubMed

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Herpes simplex type 1 (HSV‑1) is a widespread pathogen responsible for orolabial lesions. It is an enveloped, double-stranded DNA (dsDNA) virus belonging to the family Herpesviridae. Once the virus infects a host cell, its double‑stranded DNA genome is delivered into the nucleus, where a coordinated cascade of immediate‑early, early, and late gene expression directs viral DNA replication, structural protein synthesis, and virion assembly. After primary infection of epithelial cells, HSV-1...