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[Retinal periphlebitis in multiple sclerosis. A prospective study]

J Río1, A Colín, F Salvador

  • 1Servicio de Neurología, Universitària de la Vall d'Hebron, Barcelona.

Neurologia (Barcelona, Spain)
|October 1, 1993
PubMed
Summary
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Retinal periphlebitis occurred in 12.5% of multiple sclerosis patients, suggesting a vascular role in disease pathogenesis. Though not linked to severe disease, it can cause vision loss, but responds to immunosuppressive treatment.

Area of Science:

  • Ophthalmology
  • Neurology
  • Immunology

Context:

  • Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system.
  • Retinal periphlebitis, inflammation of the retinal blood vessels, is a known ocular manifestation in some neurological conditions.

Purpose:

  • To determine the frequency of retinal periphlebitis in patients with clinically defined multiple sclerosis.
  • To explore the potential link between retinal periphlebitis and the pathogenesis of multiple sclerosis.

Summary:

  • Twenty-four patients with multiple sclerosis were prospectively evaluated for retinal periphlebitis.
  • Retinal periphlebitis was identified in 12.5% of cases (3 out of 24 patients).
  • While not associated with severe or progressive MS, one patient experienced unilateral vision loss (amaurosis) due to this condition. Immunosuppressive therapy showed efficacy in one instance.

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Impact:

  • The findings suggest a potential vascular mechanism in the pathogenesis of multiple sclerosis, especially given the absence of myelin in the retina.
  • This study highlights the importance of ophthalmological examination in multiple sclerosis patients to detect potential complications like retinal periphlebitis.
  • Early detection and management of retinal periphlebitis may help prevent severe visual impairment in multiple sclerosis patients.