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Polyanionic hydrogel as a gastric retentive system
S H Leung1, B K Irons, J R Robinson
1Columbia Research Laboratories, Madison, WI 53713.
Journal of Biomaterials Science. Polymer Edition
|January 1, 1993
Summary
Gastric retention of polycarbophil (PC) hydrogel in dogs increases with viscosity. Increasing PC hydrogel viscosity prolongs its gastric emptying time, offering potential for controlled drug delivery.
Area of Science:
- Gastroenterology
- Polymer Science
- Pharmacokinetics
Background:
- Gastric emptying is crucial for drug absorption and efficacy.
- Hydrogels offer potential for controlled release applications.
- Polycarbophil (PC) is a polyanionic hydrogel with swelling properties.
Purpose of the Study:
- To investigate the effect of polycarbophil (PC) hydrogel viscosity on gastric emptying in canines.
- To determine factors influencing the gastric retention time of PC hydrogel.
- To explore the potential of PC hydrogel for creating a 'fed' state in the stomach.
Main Methods:
- Duodenal cannulation technique in fasted canines.
- Oral administration of varying amounts of PC hydrogel in water with buffering agents.
- Measurement of gastric emptying lag time.
- Assessment of viscosity and pH effects on hydrogel retention.
Main Results:
- Gastric emptying lag time increased with the viscosity of the administered PC hydrogel.
- Addition of sodium bicarbonate increased PC hydrogel's apparent viscosity and gastric retention.
- Stomach acid secretion reduced PC hydrogel viscosity via protonation, initiating discharge.
Conclusions:
- Gastric retention of PC hydrogel can be prolonged by increasing its apparent viscosity.
- The viscosity of PC hydrogel is a key factor in its gastric emptying profile.
- PC hydrogel's properties suggest potential for modulating gastric residence time.