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Related Experiment Videos

Stabilized compressed nitroglycerin tablets

F W Goodhart, H Gucluyildiz, R E Daly

    Journal of Pharmaceutical Sciences
    |October 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

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    A new stabilized compressed nitroglycerin tablet formulation demonstrated superior stability and uniformity compared to existing molded tablets. This innovation offers a more reliable nitroglycerin delivery system for patients.

    Area of Science:

    • Pharmaceutical Sciences
    • Drug Formulation
    • Nitroglycerin Stability

    Background:

    • Nitroglycerin tablets are crucial for managing angina.
    • Molded nitroglycerin tablets often suffer from stability issues due to nitroglycerin's volatility.
    • Improving the stability and uniformity of nitroglycerin formulations is essential for consistent therapeutic efficacy.

    Purpose of the Study:

    • To formulate and evaluate a stabilized compressed nitroglycerin tablet.
    • To compare the bioavailability and physical characteristics of the new compressed tablet against leading molded brands.
    • To assess the stability of the novel formulation under various conditions.

    Main Methods:

    • Formulation of a compressed nitroglycerin tablet using microcrystalline cellulose and providone as stabilizers.

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  • Bioavailability and physical testing (weight variation, content uniformity) of compressed and molded tablets.
  • Stability testing including open dish test, thermogravimetric analysis, and simulated in-use tests to evaluate nitroglycerin loss.

    • Main Results:

    • No significant difference in mean pulse rate was observed between compressed and molded tablets in a crossover study with human volunteers.
    • The stabilized compressed tablet exhibited superior uniformity in weight variation and content uniformity according to USP methods.
    • Stability tests indicated the compressed tablet was substantially more stable, with less nitroglycerin loss due to volatility compared to molded tablets.

    Conclusions:

    • The stabilized compressed nitroglycerin tablet formulation offers enhanced stability and uniformity.
    • This novel formulation presents a more robust and reliable alternative to conventional molded nitroglycerin tablets.
    • Further clinical evaluation may confirm improved therapeutic consistency and patient outcomes.