Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Oncogenes: present status

T S Vats1, A Emami

  • 1University of Kansas Medical Centre, Kansas City 66160-7357.

Indian Journal of Pediatrics
|March 1, 1993
PubMed
Summary
This summary is machine-generated.

Oncogenes and anti-oncogenes are key to cancer development and suppression. Understanding their roles aids in cancer diagnosis, prognosis, and therapy, though therapeutic applications require further research.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A decade genetic diversity in Circulating influenza B virus in Iran (2010-2019): Divergence from WHO-recommended vaccine strains.

Voprosy virusologii·2023
Same author

[Comparison of planimetric CT‑based volumetry with simplified models for determining the size of intrapelvic hematomas due to pelvic fractures in emergency room diagnostics].

Unfallchirurgie (Heidelberg, Germany)·2023
Same author

Corrigendum to "National Trends in Orthopaedic Surgery Resident Adult Case Logs" J Surg Educ. 2019 May - Jun;76(3):893-897.

Journal of surgical education·2019
Same author

Effects of dietary olive leaves on performance, carcass traits, meat stability and antioxidant status of fattening Mahabadi male kids.

Meat science·2019
Same author

The effect of grapeseed oil on performance, rumen fermentation, antioxidant status and subcutaneous adipose fatty acid profile in lambs.

Journal of animal physiology and animal nutrition·2017
Same author

Microscopic characterization of Pseudomonas Aeruginosa confines separate from clinical cases by testing RAPD-PCR method.

Journal of medicine and life·2017
Same journal

Bilateral Parotid Enlargement as an Initial Manifestation of Pediatric Acute Lymphoblastic Leukemia.

Indian journal of pediatrics·2026
Same journal

Hemorrhagic Cardiac Tamponade Due to MRSA Sepsis in a Child with Relapsed Acute Lymphoblastic Leukemia: Authors' Reply.

Indian journal of pediatrics·2026
Same journal

A Prospective Model for Detecting Missed Appendicitis in Low-Risk Pediatric Patients: Correspondence.

Indian journal of pediatrics·2026
Same journal

Serum Periostin as a Biomarker in Pediatric Asthma: Findings from a Case-Control Study - Authors' Reply.

Indian journal of pediatrics·2026
Same journal

When the Eye Peels: An Unusual Harbinger of Kawasaki Disease - Correspondence.

Indian journal of pediatrics·2026
Same journal

Pediatric Sleep-Related Laryngospasm: Cause of Nocturnal Respiratory Distress.

Indian journal of pediatrics·2026
See all related articles

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Oncogenes (viral and cellular proto-oncogenes) regulate cell growth and development.
  • Mutations activate proto-oncogenes, leading to uncontrolled cell proliferation and cancer.
  • Anti-oncogenes normally suppress tumor formation; their inactivation promotes malignancy.

Purpose of the Study:

  • To review the role of oncogenes and anti-oncogenes in cancer.
  • To discuss their diagnostic, prognostic, and therapeutic implications.
  • To explore the potential and limitations of oncogene-targeted therapies.

Main Methods:

  • Review of existing literature on oncogenes and anti-oncogenes.
  • Categorization of proto-oncogenes based on protein products (kinases, growth factors, receptors, DNA-binding proteins).

Related Experiment Videos

  • Analysis of specific oncogene/anti-oncogene roles in various cancers (e.g., CML, lymphomas, neuroblastomas, retinoblastoma).

    • Main Results:

    • Oncogene abnormalities are prevalent in pediatric leukemias, lymphomas, and solid tumors.
    • Anti-oncogenes are implicated in retinoblastoma, Wilms' tumor, rhabdomyosarcoma, and neuroblastoma.
    • Specific oncogenes (c-abl, bcl-2, N-myc) and anti-oncogenes (Rb) have well-defined roles in cancer and therapy.

    Conclusions:

    • Oncogene identification offers significant diagnostic and prognostic value in cancer.
    • Therapeutic targeting of oncogenes is promising but faces challenges due to potential damage to normal cells.
    • Combination therapies may maximize the therapeutic benefit of oncogene-based treatments.