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Importance of specific purine-pyrimidine amino and hydroxyl groups for efficient cleavage by a hammerhead ribozyme
H Tanaka1, H Hosaka, R Takahashi
1Department of Industrial Chemistry, Chiba Institute of Technology, Japan.
Nucleic Acids Symposium Series
|January 1, 1993
Abstract:
Subsequent of the discovery that RNA can have site specific cleavage activity, there has been a great deal of interest in the design and testing of trans-acting catalytic RNAs as therapeutic agents. We have chemically synthesized and experimentally analyzed chimeric DNA-RNA ribozymes in which the catalytic center remains as RNA.