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The synthesis of alternating alpha,beta-oligodeoxyribonucleotides with alternating (3'-->3')- and
1Division of Hematologic Products, Food and Drug Administration, Bethesda, MD 20892.
Nucleic Acids Symposium Series
|January 1, 1993
Abstract:
A simplified synthesis of alpha-2'-deoxyribonucleoside derivatives has been developed and the solid-phase preparation of antisense alpha,beta-oligodeoxyribonucleotides with alternating (3'-->3')- and (5'-->5')-internucleotidic phosphodiester linkages, targeted against HIV-1 tat mRNA, has been accomplished. Hybridization properties of these oligonucleotide analogues have been investigated.