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Human ecchordosis physaliphora and chick embryonic notochord. A comparative electron microscopic study
Virchows Archiv. A, Pathological Anatomy and Histology
|October 7, 1976
Summary
Ecchordosis physaliphora, a clival mass, shares ultrastructural features with embryonic notochord and chordoma. This finding supports their common origin from notochordal remnants.
Area of Science:
- Pathology
- Developmental Biology
- Histology
Background:
- Ecchordosis physaliphora is a rare, benign notochordal remnant typically found along the clivus.
- Understanding its ultrastructural characteristics is crucial for differential diagnosis and understanding its origin.
Purpose of the Study:
- To elucidate the ultrastructural morphology of ecchordosis physaliphora.
- To compare these features with those of the embryonic notochord and human chordoma.
- To reaffirm the notochordal origin of ecchordosis physaliphora and chordoma.
Main Methods:
- Ultrastructural analysis of ecchordosis physaliphora.
- Comparative analysis with published data on embryonic chick notochord and human chordoma.
Main Results:
- Ecchordosis physaliphora exhibits glycogen-rich intracytoplasmic vacuoles, distended endoplasmic reticulum, and abundant extracellular space.
- These ultrastructural features are consistent with those observed in the 9-day embryonal chick notochord.
- Similarities were also noted between ecchordosis physaliphora and human chordoma.
Conclusions:
- The ultrastructural findings support the hypothesis that ecchordosis physaliphora originates from notochordal rests.
- Chordomas share these characteristic ultrastructural features, further strengthening the link to notochordal remnants.