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Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections
Published on: August 30, 2014
Mucosal immunization with a subunit respiratory syncytial virus vaccine in mice
1Department of Medicine, Rochester General Hospital, NY.
Vaccine
|January 1, 1993
Abstract:
The protective efficacy of mucosal immunization with purified respiratory syncytial virus (RSV) fusion protein (F) using cholera toxin (CT) as an adjuvant was assessed in mice. Intranasal vaccination with F+CT induced F-specific serum IgG and nasal IgA and resulted in 75% protection from nasal virus replication compared with control mice. Intranasal CT+F with simultaneous parenteral F provided complete protection equivalent to intranasal live virus immunization.

