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Conditions of cyclodextrin complexation
1Department of Pharmaceutical Technology, Albert Szent-Györgyi Medical University, Szeged, Hungary.
Acta Pharmaceutica Hungarica
|September 1, 1993
Summary
Cyclodextrin (CD) research has advanced significantly, leading to new drug formulations. This study surveys key conditions for CD complexation and details successful precipitation of furosemide with beta-cyclodextrin.
Area of Science:
- Pharmaceutical Sciences
- Supramolecular Chemistry
Background:
- Cyclodextrin (CD) research has seen substantial growth over the past two decades.
- This progress is evidenced by numerous publications, patents, international symposia, and novel drug delivery systems utilizing CDs.
Purpose of the Study:
- To survey the critical conditions influencing cyclodextrin complexation.
- To present a successful method for precipitating a complex involving furosemide and beta-cyclodextrin.
Main Methods:
- Literature review of cyclodextrin complexation conditions.
- Experimental precipitation of furosemide-beta-cyclodextrin complex.
Main Results:
- Accumulated data allows for a comprehensive survey of essential CD complexation parameters.
- Successful precipitation of the furosemide-beta-cyclodextrin complex was achieved.
Conclusions:
- Cyclodextrin complexation conditions are well-defined.
- Precipitation offers a viable method for preparing specific cyclodextrin-drug complexes, exemplified by furosemide and beta-CD.