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Conditions of cyclodextrin complexation

M Kata1, F Giordano, I A Hadi

  • 1Department of Pharmaceutical Technology, Albert Szent-Györgyi Medical University, Szeged, Hungary.

Acta Pharmaceutica Hungarica
|September 1, 1993
PubMed
Summary
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Cyclodextrin (CD) research has advanced significantly, leading to new drug formulations. This study surveys key conditions for CD complexation and details successful precipitation of furosemide with beta-cyclodextrin.

Area of Science:

  • Pharmaceutical Sciences
  • Supramolecular Chemistry

Background:

  • Cyclodextrin (CD) research has seen substantial growth over the past two decades.
  • This progress is evidenced by numerous publications, patents, international symposia, and novel drug delivery systems utilizing CDs.

Purpose of the Study:

  • To survey the critical conditions influencing cyclodextrin complexation.
  • To present a successful method for precipitating a complex involving furosemide and beta-cyclodextrin.

Main Methods:

  • Literature review of cyclodextrin complexation conditions.
  • Experimental precipitation of furosemide-beta-cyclodextrin complex.

Main Results:

  • Accumulated data allows for a comprehensive survey of essential CD complexation parameters.

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  • Successful precipitation of the furosemide-beta-cyclodextrin complex was achieved.

    • Conclusions:

    • Cyclodextrin complexation conditions are well-defined.
    • Precipitation offers a viable method for preparing specific cyclodextrin-drug complexes, exemplified by furosemide and beta-CD.