[Comparative evaluation of dissolution and membrane transport methods of suppositories]

The dissolution and transport rate constants of Diaphyllin, Feldene, Naprosyn and Tilcotil suppositories originated from the same batches were studied. The dissolution tests were carried out with Desaga type flow cell. The membrane transport experiments were performed in "Mühlemann-tester" and in the own designed "membrane-diffusion cell". The values of the dissolution rate constants were higher than the diffusion rate constants. The results of the same batches of the suppositories tested in Mühlemann-tester or in the own designed membrane-diffusion cell were in good correlation. On the basis of the experiments carried out by the membrane-diffusion cell we can state that it is able to be standardised, automated and the results show good reproducibility.