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Nosocomial infection with gentamicin-carbenicillin-resistant Pseudomonas aeruginosa
Abstract:
Pseudomonas aeruginosa resistant to both gentamicin and carbenicillin was isolated with increasing frequency at the Cincinnati Veterans Administration Hospital during the period 1971 to 1974. A comparison of patients from whom P. aeruginosa was isolated during this period failed to reveal any significant clinical differences between the patients colonized or infected with resistant organisms and those colonized or infected with susceptible organisms. Overt clinical infection attributable to either organism was rare. The antibiotic-resistant organisms were isolated most frequently from urine. Isolation of the antibiotic-resistant organisms was more frequent from patients who had previously received gentamicin.
Insights
Antibiotic resistance in Pseudomonas aeruginosa to gentamicin and carbenicillin increased between 1971-1974. Resistant strains were often found in urine, especially in patients previously treated with gentamicin, with no significant clinical differences observed.
Area of Science:
- Medical Microbiology
- Clinical Infectious Diseases
- Antimicrobial Resistance
Background:
- Increasing isolation of Pseudomonas aeruginosa resistant to gentamicin and carbenicillin was observed.
- This trend occurred at the Cincinnati Veterans Administration Hospital from 1971 to 1974.
Purpose of the Study:
- To compare clinical characteristics of patients with susceptible versus resistant P. aeruginosa.
- To identify factors associated with the isolation of antibiotic-resistant P. aeruginosa.
Main Methods:
- Retrospective analysis of patient data.
- Comparison of clinical outcomes between groups with susceptible and resistant isolates.
- Analysis of patient history, including prior antibiotic exposure.
Main Results:
- No significant clinical differences were found between patients with susceptible and resistant P. aeruginosa.
- Overt clinical infections were rare for both resistant and susceptible strains.
- Resistant P. aeruginosa was most frequently isolated from urine samples.
- Prior gentamicin treatment was associated with a higher frequency of isolating resistant P. aeruginosa.
Conclusions:
- The emergence of gentamicin- and carbenicillin-resistant P. aeruginosa did not correlate with distinct clinical presentations or severity.
- Urinary tract infections and prior gentamicin use are associated with resistant P. aeruginosa.
- Surveillance for antimicrobial resistance patterns is crucial in clinical settings.