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Inhibition of dihydrofolate reductase by mofebutazon
E Strehl1, I Schneider, E F Elstner
1Institut für Botanik und Mikrobiologie, Technische Universität München, Bundesrepublik Deutschland.
Zeitschrift Fur Naturforschung. C, Journal of Biosciences
|September 1, 1993
Abstract:
Mofebutazon, in contrast to phenylbutazon, inhibits dihydrofolate reductase in a concentration-dependent manner. An apparent Ki for mofebutazon and dihydrofolate reductase in the presence of NADPH as electron donor and dihydrofolate as electron acceptor of approximately 0.2 mM was calculated.